Imagination needs reality - ideas need implementation

BioTech

Biocatalysis plays a particularly important role in establishing sustainable economic practices. More and more innovations in white biotechnology are already being used by the chemical, pharmaceutical and food industries, or are being considered for future strategic planning.

We want to have an 'enzymatic' effect for your ideas in the field of biocatalysis and minimise the activation energy necessary for new projects. You can rely on our expertise and experience in the production of enzymes at various scales and our know-how in process development and/or optimisation.

We offer you the best service

Contract manufacturing

We bring the biocatalysts, developed by our customers for industrial use, to large-scale production and guarantee the supply of the product - at the right time. The available technical equipment and production capacity enable us to respond quickly to the frequent product changes that occur in contract manufacturing.

Process development

Do you need process development or process step optimisation in addition to full-scale production?

The R&D laboratories and the pilot plant, a scaled-down copy of the production plant, can be used to carry out research projects and process development.

The pilot plant allows small quantities (up to 500 litres) to be produced for test purposes and to gain important insights for subsequent scale-ups.

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Cloning

We offer a range of cloning methods at the customer's request to make subsequent process development as efficient as possible. The cloning project is managed jointly by our molecular biology experts and process developers.

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Quality assurance

To ensure the most consistent quality possible, regular analytical checks are carried out on the batches produced. Each production batch is carefully monitored throughout the process. Depending on the specification, further microbiological analysis and activity checks are done before the finished product is released. This also ensures compliance with our strict quality system.

Find out more about quality management

Our Biotech technologies

fermentation

Lactosan has three complete fermentation lines, which are controlled by a process control system and can be fully sterilised.

Production

4 media tanks
5000l, 1000l fermentation pre-stage
2 x 15000l fermentation main stage

Pilot plant

16l fermentation pre-stage
700l, 300l, 150l fermentation main stage

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separation

Fermentation is followed by a concentration step using a separator.

Production

10000 l/h separation

Pilot plant

100 l/h separation

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homogenisation

In the homogenisation step, the biomass is broken down and the enzymes are released.

Production

2 x 1000 l/1000 bar homogenisation

Pilot plant

120 l/1000 bar homogenisation

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precipitation

In order to increase the purity of the enzyme product or to improve subsequent filtration steps, it is possible to integrate a precipitation step into the production process.

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concentration

In the enzyme production process, ultrafiltration and diafiltration systems are used to concentrate the product and for buffer exchange respectively.

Production

400 l/min crossflow ultra/diafiltration

Pilot-Plant

60 l/min crossflow ultra/diafiltration

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DNA-depletion

DNA depletion is another optional step in the enzyme production process to increase the purity of the product.

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filtration techniques

The filtration system allows removal of the production organism or components thereof in the product, at the customer's request.

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freeze-drying

The aim of freeze-drying is to obtain a dried, readily water-soluble product that retains the properties of the original product after the addition of water.