We turn your idea into a finished product

Microbial Additives

Lactosan has been developing and producing starter cultures and strains for probiotics since 1989. With decades of experience in fermentation and freeze-drying, we are able to respond flexibly and individually to the needs of our customers. From the isolation and characterisation of new strains, through process development and fermentation, to industrial-scale production and subsequent freeze-drying and packaging of the product, everything remains under one roof. A highly motivated and skilled team of microbiologists and biotechnologists will turn your idea into a finished product.

Animal Health / Human Use

In the Microbial Additives division, we have two completely separate production lines for animal nutrition probiotics and silage starter cultures on the one hand, and human probiotics and food starter cultures on the other.

Contact Animal Health Contact Human Nutrition

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Contract production

All non-GMO BSL-1 strains can be produced in our Microbial Additives facilities. On request, we can produce customer strains or individual strain mixtures according to customer processes or our own strains from our strain collection according to our proven production processes. We also offer custom process development for new strains in our pilot plant.

Process development

Our decades of experience in fermentation and lyophilisation enable us to develop a customised production process for each strain.

From the project phase through to market launch, development takes place in close collaboration with our customers. Flexibility is our strength! Whether it be allergen-free media, new excipients or special hygiene levels, our specialists respond individually and flexibly to our customers' wishes.

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Cell banks

On request, we will create a cell bank for production from the customer base. This is checked for purity, identity and growth behaviour and stored at -80°C in glycerol stocks.

Quality check

Consistent quality is a top priority at Lactosan. Each production batch is closely monitored at various stages.

This starts with the high quality raw materials from selected suppliers, which are subjected to a risk analysis and regularly analysed before use. In-process analysis includes process and quality control of the batch. A comprehensive final inspection of the powder produced to specification ensures a flawless intermediate product. After packaging, a new test is carried out against the customer's specification.

Lactosan has several laboratories for process and product monitoring. For example, genetic issues such as strain identification are carried out in our molecular biology laboratory. This ensures at all times that the strain produced corresponds with the strain supplied by the customer.

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Our Microbial Additives technologies

fermentation

Lactosan has three complete fermentation lines, which are controlled by a process control system and can be fully sterilised.

Production Microbial Additives

4 media tanks
2000 l, 1000 l, 500 l fermentation preliminary stage
2 x 10000 l, 15000 l, 50000 l fermentation main stage

Pilot plant

16 l fermentation pre-stage
700 l, 300 l, 150 l fermentation main stage

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separation

Fermentation is followed by a concentration step using a separator.

Production Microbial Additives

4 x 10000 l/h separation

Pilot plant

100 l/h separation

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freeze-drying

The aim of freeze-drying is to obtain a dried, readily water-soluble product that retains the properties of the original product after the addition of water.

Production Microbial Additives

1000 l/batch freeze-drying

Pilot-Plant

10 l/batch freeze-drying

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fluidised bed drying

In the Microbial Additives plant, it is possible to dry the bacterial concentrate in the fluidised bed plant as an alternative to freeze-drying.

Production Microbial Additives

300 kg/batch fluidised bed drying

Pilot plant

2 kg/batch fluidised bed drying

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grinding

After drying, further processing takes place on the relevant powder line. The product flakes dried by lyophilisation are crushed in mills.

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mixing

After the drying and milling process, the powder is processed on the relevant powder line and the final product is mixed according to specification.

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packaging

After processing on the relevant powder line, the dried powder is filled according to customer's requirements.

Filling Microbial Additives

500 kg big bags
300 g to 30 kg sack
2 g to 500 g bags
20 g to 1000 g tins

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storage

Appropriate storage is essential to ensure the stability of the finished products.

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Are you interested in our own strains?

Our strain collection comprises approximately 2,000 different strains and is constantly being expanded with bacterial strains isolated from natural habitats. Isolated strains are tested in-house in accordance with requirements for agglomeration, pH and bile salt tolerance and antibiotic susceptibility. Products containing our strains have been successful on the market for many years. It is possible to customise individual strains or strain mixtures with specific bacterial counts and carriers.

Ask our experts

Bifidobacterium animalis ssp. lactis

Bla02

Bifidobacterium bifidum

Bbi58

Bifidobacterium breve

Bbe56

Bifidobacterium longum subsp. infantis

Bin26

Bifidobacterium longum subsp. longum

Blo17

More strains