Lyophilization means: deprivation of water out of frozen material. The drying is conducted in the solid state of matter via sublimation – ice is directly converted to vapour. This is possible under vacuum, the temperature of the material that should be dried can be as low as -50°C. The objective of lyophilisation is to get a product that is very well watersoluble and has the characteristics of the starting material as soon as water is added. The material is dried through lyophilization and during this process most enzymatic, bacterial and chemical alterations do not occur. Therefore lyophilization is the gentlest method at all to conserve biological materials. At Lactosan the lyophilization is mainly used for the conservation of lactic acid bacteria that are used as biological silage inoculants.


Process steps

  • Freezing of material according to optimized time and temperature limits
  • Lyophilization (sublimation) according to definded time-, temperature- and pressure values
  • Post-drying of products according to time and temperature limits



Production 800 l / batch
Pilot plant 60 l / batch

After lyophilization the dried material is grinded to a fine powder. The sophisticated mill used fulfills all requirements of the ATEX regulation (mandatory in Europe). The grinded powder is collected in a closable container made of stainless steel and the batch is homogenously mixed with a column mixing unit.

The lyophilization facility is located in a separate clean room area with locks for personel and material.


Industrial cleaner

An industrial cleaner with standardized cleaning programs is available for the cleaning of all parts in contact with the product. Sanitizing is carried out using a drying programm with a temperature of 105°C.